Epinephrine - Because of the likely for promethazine to reverse epinephrine’s vasopressor influence, epinephrine shouldn't be used to take care of hypotension linked to promethazine overdose.

For nausea and vomiting in little ones, the usual dose is 0.5 mg for every pound of physique fat, plus the dose really should be altered on the age and excess weight in the affected person and the severity from the problem getting dealt with.

Anticholinergics– Concomitant use of other agents with anticholinergic Houses really should be undertaken with warning.

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Codeine has reduced plasma protein binding with about 7 to twenty five% of codeine sure to plasma proteins. Codeine passes the blood brain barrier as well as placental barrier. Little quantities of codeine and its metabolite, morphine, are transferred to human breast milk.

For prescriptions where a measuring product just isn't presented, a pharmacist can provide an proper calibrated measuring gadget and can provide instructions for measuring the proper dose.

Lower Seizure Threshold - Promethazine may possibly reduce seizure threshold. It should be made use of with warning in people with seizure Issues or in folks that are utilizing concomitant medications, for instance narcotics or regional anesthetics, which may also influence seizure threshold.

Promethazine HCl and Codeine Phosphate Oral Option is indicated to the short-term check here reduction of coughs and higher respiratory indicators affiliated with allergy or perhaps the frequent chilly in individuals 18 several years of age and more mature.

Although antihistamines have already been uncovered to produce fetal mortality in rodents, the pharmacological results of histamine while in the rodent will not parallel Those people in man. There aren't any enough and perfectly-managed scientific tests of promethazine in Expecting Women of all ages.

Anaphylactic reactions, as adjunctive therapy to epinephrine and also other standard measures, following the acute manifestations happen to be controlled.

Be sure that clients have an oral dosing dispenser that measures the right volume in milliliters. Counsel patients regarding how to benefit from an oral dosing dispenser and properly measure the oral suspension as prescribed.

The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients lower than 6 yrs of age, because The mix may perhaps cause lethal respiratory despair With this age populace (see WARNINGS Box Warning and Use in Pediatric Sufferers).

The typical successful dose of Promethazine HCl Oral Resolution to the Energetic therapy of nausea and vomiting in young children or Grown ups is 25 mg.

Area the mixture in a very container like a sealed plastic bag and throw it away inside the family trash. You may as well comply with your state or area recommendations regarding how to safely and securely toss away Promethazine Hydrochloride and Codeine Phosphate Oral Option.